Cobicistat will improve the degree or outcome of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. elvitegravir/cobicistat/emtricitabine/tenofovir DF increases amounts of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. nifedipine will improve the level or effect of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 met... https://rad51-inhibitor-b0243220.therainblog.com/26362283/2-fundamentals-explained