Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts from your microenvironment and expanding the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have discovered recurrent mutations in genes regulating tumor cell-microenvironment interactions, whi... https://jonathany233bmw6.popup-blog.com/profile