Antisense oligonucleotides (ASOs) were the first modality to pioneer targeted gene knockdown in the treatment of amyotrophic lateral sclerosis (ALS) caused by mutant superoxide dismutase 1 (SOD1). RNA interference (RNAi) is another mechanism of gene silencing in which short interfering RNAs (siRNAs) effectively degrade complementary transcripts. However. delivery to extrahepatic tissu... https://www.roneverhart.com/5-15P-ANGLE-PLUG-B-W-HUBBELL-HBL5266CA/